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- 125articles · 30d
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News
Detecting Contamination and Cross-Talk in Sequencing Data
2+ day, 20+ hour ago (128+ words) Table 1: Summary of contamination types in NGS data, with characteristic data signatures and recommended analytical detection tools. Reads with unexpected or mismatched index combinations Unique dual index audit, per-library read-count review A systematic approach for evaluating a sample flagged for…...
AI Method Supports Real-Time Management of Infectious Diseases
1+ week, 4+ day ago (187+ words) These phylogenetic trees are built using algorithms, which suggest the most likely tree based on the available genetic data. Various parameters can be estimated, such as the rate at which a pathogen spreads, the duration of infection, its geographical origin,…...
Living Bacterial Circuits Mimic Electronic Transistors
3+ week, 3+ day ago (620+ words) MIT researchers have engineered bacteria that can function as transistors, allowing the team to create living “circuit boards” that can be printed onto a growth medium in a Petri dish. In electrical circuits, transistors function as switches that can turn…...
Improving Consistency and Scalability in AAV Manufacturing
3+ week, 4+ day ago (896+ words) Adeno-associated virus (AAV) vectors remain one of the leading delivery platforms for gene therapies, but manufacturing them at commercial scale continues to present significant challenges. As gene therapies expand beyond rare diseases toward larger patient populations and complex indications, more…...