2+ day, 16+ hour ago   (128+ words) Table 1: Summary of contamination types in NGS data, with characteristic data signatures and recommended analytical detection tools. Reads with unexpected or mismatched index combinations Unique dual index audit, per-library read-count review A systematic approach for evaluating a sample flagged for…...

2+ day, 16+ hour ago   (156+ words) Mapped 5' start position Mapped start position and UMI sequence Distinguishes independent molecules at the same position Appropriate for WGS germline variant calling Yes, with added overhead Appropriate for deep targeted panel sequencing No; removes genuine fragments Yes, via consensus calling…...

2+ day, 21+ hour ago   (596+ words) More than two decades after scientists first sequenced the entire human genome — all 3 billion “letters,” or base pairs, of DNA code — the meaning of much of this code remains a mystery. Researchers at UC Berkeley have created a new genomic language…...

3+ day, 17+ hour ago   (200+ words) Technology Networks Connect these carbon triangles to an amine, a functional group with a nitrogen at its center, and you get aminocyclopropanes. They are of particular interest in pharmaceutical research because they can be used to replace another substructure commonly…...

3+ day, 21+ hour ago   (580+ words) As an embryo develops from a small cluster of stem cells, those once “blank slate” cells begin to take on more specialized roles like brain, liver, or muscle cells, and organize themselves into three-dimensional structures such as tissues and organs....

4+ day, 14+ hour ago   (222+ words) Table 1: Comparison of poly-A selection and ribosomal RNA depletion for RNA library preparation across key decision parameters. Limited; many lncRNAs partially or fully excluded Performance on degraded RNA Strong 3' end bias Relative sequencing depth needed Figure 1: A comparison of poly-A…...

5+ day, 21+ hour ago   (239+ words) The human body and its gut microbiome produce thousands of small molecules that shape how the body functions—influencing immunity, metabolism, and more. Identifying what those molecules actually are has been one of the biomedical sciences’ most persistent bottlenecks. More…...

1+ week, 2+ day ago   (457+ words) Evolution has created an astonishing amount of diversity, shaping much of our understanding of biology. But this diversity, which took billions of years to emerge, barely scratches the surface of what could have existed given the trillions of possible DNA…...

1+ week, 3+ day ago   (251+ words) Spatial transcriptomics is a powerful tool to create a detailed map of not just how genes are expressed in a piece of tissue, but also where genetic activity takes place in different cells and locations within the tissue. This is…...

1+ week, 3+ day ago   (16+ words) Technology Networks Download this infographic to discover:...